Publications by authors named "L J Hutchinson"
This study evaluates the use of poly(vinyl alcohol), collagen, and chitosan blends for developing a microneedle patch for the delivery of meloxicam (MEL). Results confirm successful MEL encapsulation, structural integrity, and chemical stability even after ethylene oxide sterilization. Mechanical testing indicates the patch has the required properties for effective skin penetration and drug delivery, as demonstrated by load-displacement curves showing successful penetration of pig ear surfaces at 3N of normal load.
View Article and Find Full Text PDFBackground: Allogeneic stem cell transplant (allo-SCT) is a mainstay of treatment for acute myeloid leukemia (AML). Its success depends largely on response of donor T lymphocytes against leukemia cells, known as graft-vs-leukemia (GvL) effect. A key potential driver of GvL is immune response to mutation-derived neoantigens.
View Article and Find Full Text PDFThe multifaceted IL-2/IL-2R biology and its modulation by promising therapeutic agents are highly relevant topics in the cancer immunotherapy field. A novel CD25-Treg-depleting antibody (Vopikitug, RG6292) has been engineered to preserve IL-2 signaling on effector T cells to enhance effector activation and antitumor immunity, and is currently being evaluated in the clinic. The Entry into Human-enabling framework described here investigated the characteristics of RG6292, from in vitro quantification of CD25 and RG6292 pharmacology using human tissues to in vivo assessment of PK/PD/safety relationships in cynomolgus monkeys as non-human primate species (NHP).
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- The study developed the Clonal Hematopoiesis Risk Score (CHRS) to assess the risk of clonal hematopoiesis (CH) in healthy individuals, but recognized that most CH cases are diagnosed when symptoms appear.
- Researchers examined clinical data from 94 CH patients, distinguishing between those with only DNMT3A/TET2/ASXL1 mutations ('sole DTA') and those with additional mutations ('non-sole DTA').
- Results revealed that TET2 was the most common mutation, sole DTA patients rarely progressed to myeloid neoplasm (MN), while non-sole DTA patients had a significant progression rate, especially if they had a RUNX1 mutation, indicating higher risk
Article Synopsis
- * Researchers analyzed 77 patients' biopsies using immunohistochemistry (IHC) and confirmed findings with molecular tests, revealing that 18.2% tested positive for Chlamydia.
- * The results indicate that Chlamydia infection is more common in patients with active proctitis, suggesting that IHC could be used as a screening tool to identify this condition early in high-risk populations.