Background: This study aimed to identify molecular markers that influence liver metastasis in colorectal cancer (CRC) and assess their clinical relevance.
Methods: Proteomic analysis compared differential protein expression between CRC patients with liver metastasis (CRLM) and those without (CRNLM). Bioinformatics and survival analyses identified key proteins and validated them using the TCGA database for expression and clinical significance.
The changes in structural, interfacial, antioxidant, and emulsifying properties of pectin after grafting surfactin were investigated. Surfactin-pectin conjugate exhibited the highest surface hydrophobicity, approximately 130-fold of surfactin and 1.4-fold of pectin, accompanied by changed FTIR spectra.
View Article and Find Full Text PDFLignin is the most prevalent by-product of the pulp and paper industry and the world's second most abundant naturally occurring renewable biopolymer, after cellulose. Among various lignin-based materials, lignin nanoparticles (LNPs) are inexpensive and easily biodegradable by fungi and bacteria in nature, considered as a valuable class of renewable resources. Additionally, LNPs are not biotoxic and do not cause tissue rejection.
View Article and Find Full Text PDFMethotrexate (MTX) is a critical antimetabolite drug in treating various pediatric diseases, including acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma (NHL), brain tumors, osteosarcoma, inflammatory myofibroblastic tumor (IMT), juvenile scleroderma (JS), and juvenile idiopathic arthritis (JIA). MTX acts as a folate antagonist by inhibiting dihydrofolate reductase (DHFR), an enzyme essential for the synthesis of tetrahydrofolate. This disruption impairs DNA synthesis, repair, and cellular replication, particularly affecting rapidly dividing cells.
View Article and Find Full Text PDFBiochim Biophys Acta Mol Basis Dis
March 2025
N6-methyladenosine (mA) RNA methylation is crucially involved in the genesis and advancement of gastric cancer (GC) by controlling various pathobiological aspects including gene expression, signal transduction, metabolism, cell death, epithelial-mesenchymal transition, angiogenesis, and exosome function. Despite its importance, the exact mechanisms by which mA modification influences GC biology remain inadequately explored. This review consolidates the latest advances in uncovering the mechanisms and diverse roles of mA in GC and proposes new research and translational directions.
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