Proteomics-driven discovery of LCAT as a novel biomarker for liver metastasis in colorectal cancer.

Background: This study aimed to identify molecular markers that influence liver metastasis in colorectal cancer (CRC) and assess their clinical relevance.

Methods: Proteomic analysis compared differential protein expression between CRC patients with liver metastasis (CRLM) and those without (CRNLM). Bioinformatics and survival analyses identified key proteins and validated them using the TCGA database for expression and clinical significance.

Improvement of interfacial, antioxidant, and emulsifying properties of pectin by grafting surfactin.

The changes in structural, interfacial, antioxidant, and emulsifying properties of pectin after grafting surfactin were investigated. Surfactin-pectin conjugate exhibited the highest surface hydrophobicity, approximately 130-fold of surfactin and 1.4-fold of pectin, accompanied by changed FTIR spectra.

Cutting-edge innovations in lignin-based nanoparticles: A review of synthesis techniques, characterization, and diverse applications.

Lignin is the most prevalent by-product of the pulp and paper industry and the world's second most abundant naturally occurring renewable biopolymer, after cellulose. Among various lignin-based materials, lignin nanoparticles (LNPs) are inexpensive and easily biodegradable by fungi and bacteria in nature, considered as a valuable class of renewable resources. Additionally, LNPs are not biotoxic and do not cause tissue rejection.

Methotrexate resistance and its regulatory mechanisms in pediatric tumors and beyond.

Methotrexate (MTX) is a critical antimetabolite drug in treating various pediatric diseases, including acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma (NHL), brain tumors, osteosarcoma, inflammatory myofibroblastic tumor (IMT), juvenile scleroderma (JS), and juvenile idiopathic arthritis (JIA). MTX acts as a folate antagonist by inhibiting dihydrofolate reductase (DHFR), an enzyme essential for the synthesis of tetrahydrofolate. This disruption impairs DNA synthesis, repair, and cellular replication, particularly affecting rapidly dividing cells.

N6-methyladenosine RNA modification in stomach carcinoma: Novel insights into mechanisms and implications for diagnosis and treatment.

N6-methyladenosine (mA) RNA methylation is crucially involved in the genesis and advancement of gastric cancer (GC) by controlling various pathobiological aspects including gene expression, signal transduction, metabolism, cell death, epithelial-mesenchymal transition, angiogenesis, and exosome function. Despite its importance, the exact mechanisms by which mA modification influences GC biology remain inadequately explored. This review consolidates the latest advances in uncovering the mechanisms and diverse roles of mA in GC and proposes new research and translational directions.