Publications by authors named "L J HURWITZ"
Purpose: Surgery, an established short-term immunosuppressive event, may spur dissemination of circulating tumor cells and promote the growth of micrometastases. Whether surgical treatment for prostate cancer (i.e.
View Article and Find Full Text PDFBackground: Pollutants including metals/metalloids, nitrate, disinfection byproducts, and volatile organic compounds contaminate federally regulated community water systems (CWS) and unregulated domestic wells across the United States. Exposures and associated health effects, particularly at levels below regulatory limits, are understudied.
Objective: We described drinking water sources and exposures for the California Teachers Study (CTS), a prospective cohort of female California teachers and administrators.
Background: Atrazine is a common agricultural herbicide in the United States. Few epidemiologic studies have evaluated cancer risks. Previous analyses within the Agricultural Health Study (AHS) have found some evidence of associations with cancer at some sites.
View Article and Find Full Text PDFArticle Synopsis
- Over 200 genetic variants linked to prostate cancer risk were identified, with specific pesticides (like fonofos and malathion) also associated with increased risk among farmers.
- Researchers analyzed data from 1,162 prostate cancer cases and 2,206 controls, examining the effects of pesticide use alongside a polygenic risk score (PRS) based on 256 genetic variants.
- Findings showed that men who used certain pesticides, particularly fonofos, combined with a higher genetic risk score had elevated chances of developing both total and aggressive prostate cancer, indicating that pesticide exposure might amplify genetic susceptibility.
Background: Though obesity, measured by body mass index (BMI), is an established risk factor for several cancer sites, there is conflicting evidence on whether obesity increases prostate cancer risk or mortality and, if it does, whether it increases risk directly or indirectly by affecting prostate cancer screening efficacy.
Methods: We examined associations between BMI and prostate cancer screening outcomes, incidence, and mortality in men randomly assigned to the intervention arm of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (n = 36 756) between 1993 and 2001. Participants received annual screening with the prostate-specific antigen test and digital rectal exam.