Publications by authors named "L J Gleeson"
Article Synopsis
- - Airway macrophages (AM) are key immune cells in the lungs that help protect against infections, making them important for targeted therapies aimed at enhancing immune responses.
- - The study investigates how different types of macrophages respond to signaling molecules (IFN-γ and IL-4) that represent immune responses in the lungs, finding that AM rely heavily on glycolysis for their functions, especially in cytokine production.
- - Results show that AM exhibit unique metabolic responses and functional plasticity compared to monocyte-derived macrophages (MDM), suggesting that AM could be effective targets for new inhaled treatments for lung diseases.
Article Synopsis
- Tissue-resident natural killer (trNK) cells are found in the human lung, and this study investigates their unique metabolic functions, which may play a role in their effectiveness as immune cells.
- Researchers analyzed human bronchoalveolar lavage fluid (BALF) and peripheral blood using flow cytometry and SCENITH to compare the phenotype and metabolism of NK cells in these locations, uncovering specific markers for trNK cells.
- The study discovered that lung NK cells have a significantly higher glycolytic capacity and are more reliant on glucose than those in peripheral blood, suggesting these trNK cells are better equipped to respond to challenges in the lung environment.
Unlabelled: Pleural tuberculosis (TB) is a common entity with similar epidemiological characteristics to pulmonary TB. It represents a spectrum of disease that can variably self-resolve or progress to TB empyema with severe sequelae such as chronic fibrothorax or empyema necessitans. Coexistence of and progression to pulmonary TB is high.
View Article and Find Full Text PDFHere we describe three cases of sarcoidosis which were diagnosed following COVID infection. Treating clinicians should consider post-COVID-19 sarcoidosis in their differential, as it represents a potentially treatable cause of persistent symptomatology.
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