Publications by authors named "L J Geskin"
Purpose: Denileukin diftitox (DD)-cxdl is a fusion protein comprising diphtheria toxin fragments A and B and human interleukin-2. This phase III, multicenter, open-label, single-arm registrational trial evaluated the efficacy and safety of DD-cxdl in patients with relapsed/refractory (R/R) cutaneous T-cell lymphoma (CTCL).
Patients And Methods: In the main study, which followed a dose-finding lead-in, DD-cxdl was administered intravenously daily (5 days; 9 µg/kg/d once daily) every 21 days for up to eight cycles.
Background: Mycosis fungoides (MF) is the most common form of cutaneous T cell lymphoma. While multiple guidelines provide treatment recommendations, there are currently no clear treatment algorithms for MF. Chlormethine gel is recommended by major treatment guidelines as a first-line option for stage IA-IIA disease, and, on the basis of these guidelines, used in combination with other therapies in patients with advanced-stage MF in clinical practice.
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- Paclitaxel is a common treatment for breast, ovarian, and lung cancers, but its use can be hindered by hypersensitivity reactions, potentially affecting about 11.9% of patients.
- A study at Memorial Sloan Kettering analyzed 12,274 patients, revealing that factors like younger age, race, and allergy history were significant predictors of these immediate and delayed reactions, particularly in breast cancer patients.
- Understanding these risk factors can help healthcare providers make better treatment decisions and consider alternatives like switching to nab-paclitaxel if patients experience troublesome skin reactions.
Article Synopsis
- Regular use of OTC sunscreen is crucial for preventing skin cancer, but it is rarely covered by Medicaid plans across the U.S.
- A review of 111 Medicaid preferred drug lists revealed that only five states cover sunscreen, putting a financial burden on low-income individuals and families.
- The text analyzes the current Medicaid policies on sunscreen coverage and estimates the costs related to this essential skin cancer prevention method.