Publications by authors named "L J Fairbairn"
Objective: The objective of this review is to investigate the use of the subcutaneous route of administration of analgesics, common practice within palliative medicine.
Design: Systematic review using consensus approach, direct comparison of subcutaneous route with intravenous and intramuscular routes.
Results: The limited available evidence demonstrates non-inferiority of the subcutaneous route in both cancer patients and those post-surgery.
Article Synopsis
- * Researchers analyzed data from 33,625 LTOT patients from January 2015 to June 2019 and identified 65 opioid overdoses during the follow-up period, 11 of which were fatal.
- * The revised overdose risk model showed improved predictive accuracy with a C-statistic of 0.77, making it easier for healthcare providers to assess patient overdose risks while highlighting the need for customized models based on local clinical needs.
Article Synopsis
- Peatlands in high latitudes act as long-term carbon sinks due to the higher production of plant biomass during the growing season compared to carbon loss in the non-growing season.
- As temperatures rise, particularly during the colder months, there are concerns that the decomposition of organic material in these soils will accelerate, leading to increased carbon dioxide (CO₂) emissions from northern peatlands.
- Laboratory tests showed that boreal peat soils produced CO₂ at a higher rate with temperature increases compared to temperate soils, indicating that typical models may not accurately predict emissions, especially during freeze-thaw cycles.
Article Synopsis
- The FANTOM5 project mapped transcription initiation events in human and mouse genomes with high precision using CAGE technology and single-molecule sequencing.
- Over 3,000 diverse samples, including primary cells and tissues, were analyzed through a standardized process starting from RNA quality assessment to generating transcription initiation frequencies.
- The analysis identified around 200,000 (human) and 150,000 (mouse) non-overlapping peaks, enabling the annotation of both known and novel promoters and providing insights into transcriptional regulation in different cellular states.
Objectives: Post-traumatic stress disorder is characterized by impaired fear extinction and excessive anxiety. D-Cycloserine (DCS) has previously been shown to facilitate fear extinction and decrease anxiety in animal and human studies. This study utilized a contextual fear-conditioning animal model to investigate the involvement of microRNAs (miRNAs) in fear extinction and the reduction of anxiety, as mediated by the co-administration of DCS and behavioural fear extinction.
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