Publications by authors named "L J Eyrolle"
Article Synopsis
- Pelvic bone and soft tissue sarcoma surgeries have a high risk of surgical site infections (SSIs), prompting a study to evaluate whether extending antibiotic prophylaxis (ABP) from the standard 24-48 hours to 5 days would lower this risk.
- The study analyzed data from 146 patients, revealing that 41% developed SSIs, with no significant difference in rates between those receiving extended ABP (46.4%) and standard ABP (39.8%).
- Key risk factors for developing SSIs included longer surgery duration, extended postoperative ICU stays, and use of specific surgical flaps, while the extended ABP did not show a benefit in reducing infections, which were most commonly polymicrobial.
Objectives: This study aimed at characterizing the pharmacokinetics (PK) of oral levofloxacin in adult patients in order to optimize dosing scheme and explore the PK/pharmacodynamics (PD) of levofloxacin in bone and joint infections (BJIs).
Methods: From November 2015 to December 2019, all patients hospitalized in Cochin Hospital, treated with levofloxacin and who had at least one dosage for therapeutic drug monitoring were included. PK was described using non-linear mixed-effect modelling.
Purpose: The SARS-CoV-2 epidemic started in December 2019 in Wuhan. The lockdown was declared on March 16, 2020 in France. Our centre had to adapt daily practices to continue to take care of bone and soft tissue tumours and emergencies.
View Article and Find Full Text PDFObjectives: One-stage replacement arthroplasty for treatment of periprosthetic joint infection (PJI) results in similar cure rate than two-stage (around 85-92%), but antibiotic therapy duration is not well established. The aim of this study was to evaluate the efficacy of a short six-week antibiotic course in periprosthetic joint infections after onstage exchange.
Patients And Methods: Retrospective, observational study conducted at Orthopaedic Department of Cochin Hospital, Paris, between 1st January 2010 and 31 December 2015.
Background: Postoperative delirium occurs frequently in elderly hip fracture surgery patients and is associated with poorer overall outcomes. Because xenon anaesthesia has neuroprotective properties, we evaluated its effect on the incidence of delirium and other outcomes after hip fracture surgery.
Methods: This was a phase II, multicentre, randomized, double-blind, parallel-group, controlled clinical trial conducted in hospitals in six European countries (September 2010 to October 2014).