Health related quality of life in patients with total hip or knee replacement.

Objective: The Quality of Well Being index (QWB) and the SF-36 are questionnaires that have received widespread use in outcomes research. The relationship between the QWB index and the SF-36 was studied in patients receiving total hip or knee replacement because of primary osteoarthritis, and the health status of these individuals was contrasted to that of the general population.

Design: The QWB and SF-36 were both administered preoperatively and postoperatively and at 3 and 6 months in individuals with hip or knee replacement.

Evaluation of health-related quality of life in individuals with vestibular disease using disease-specific and general outcome measures.

Background And Purpose: The Dizziness Handicap Inventory (DHI) is a condition-specific health status measure for persons with vestibular disease, and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) is a generic health status assessment. The purposes of this study were (1) to describe the relationship between the DHI and the SF-36, (2) to examine the reliability and responsiveness of these measures for persons in a vestibular rehabilitation program, and (3) to compare health-related quality of life between individuals with vestibular disease and the general population.

Subjects: Ninety-five patients, aged 25 to 88 years (mean = 57.

Total hip and knee replacement treatment programs: a report using consensus.

Physical therapists may use varied treatment protocols for the acute care of patients with to hip or knee replacements. The purpose of this study was to develop, via consensus, a standardized treatment program for patients receiving total hip or knee replacement for primary osteoarthritis. Eighteen clinicians nationwide participated in a three-round consensus process.

Reliability, validity, and responsiveness of functional tests in patients with total joint replacement.

Background And Purpose: High-quality measurements are needed to develop meaningful clinical practice databases to assess the effectiveness of physical therapy. This study determined the reliability, validity, and responsiveness of measurements obtained with five functional tests graded with the newly developed Iowa Level of Assistance Scale.

Subjects And Methods: Eighty-six patients with total hip or knee replacements were tested at various time periods during their hospitalization.

Neurotensin(8-13): comparison of novel analogs for stimulation of cyclic GMP formation in neuroblastoma clone N1E-115 and receptor binding to human brain and intact N1E-115 cells.

Neurotensin(8-13), the carboxyl-terminal portion of neurotensin, is 4-50 times more potent than native neurotensin in binding to intact neuroblastoma N1E-115 cells and human brain tissue and in stimulation of intracellular cyclic GMP production and inositol phospholipid hydrolysis in clone N1E-115 (Gilbert JA and Richelson E, Eur J Pharmacol 99: 245-246, 1984; Gilbert JA et al., Biochem Pharmacol 35: 391-397, 1986; Kanba KS et al., J Neurochem 46: 946-952, 1986; and Kanba KS and Richelson E, Biochem Pharmacol 36: 869-874, 1987).