Bronchiolitis in adults: etiology, diagnostic and therapeutic approach.

Background: Bronchiolitis is a heterogeneous group of disorders, each with its own clinical and radiographic presentation, treatment options and prognosis. Until now classifications were based on pathology and radiology.

Summary: Bronchioles are smaller than 2mm in diameter and do not contain cartilage and mucous glands in their walls.

Population Dynamics of the Exotic Flatworm in an Invaded Garden.

Population dynamics and the way abundance fluctuates over time may be key determinants of the invasion success of an introduced species. Fine-scale temporal monitoring of invasive species is rarely carried out due to the difficulties in collecting data regularly and over a long period. Thanks to the collaboration of an amateur naturalist, a unique dataset on the abundance of the invasive land flatworm was obtained during a 4-year survey of a French private garden, where up to 1585 were recorded in 1 month.

[Mental health after treatment with elexacaftor/tezacaftor/ivacaftor in end-stage cystic fibrosis].

Background: Studies showed significant physical improvement after starting elexacaftor/tezacaftor/ivacaftor (ETI). However, some patients reported new mental health symptoms.

Aim: This study explores the impact of ETI on end-stage cystic fibrosis patients, focusing on mental health.

Functional MRGPRX2 expression on peripheral blood-derived human mast cells increases at low seeding density and is suppressed by interleukin-9 and fetal bovine serum.

Primary human mast cells (MC) obtained through culturing of blood-derived MC progenitors are the preferred model for the study of MRGPRX2- IgE-mediated MC activation. In order to assess the impact of culture conditions on functional MRGPRX2 expression, we cultured CD34-enriched PBMC from peripheral whole blood (PB) and buffy coat (BC) samples in MethoCult medium containing stem cell factor (SCF) and interleukin (IL)-3, modified through variations in seeding density and adding or withholding IL-6, IL-9 and fetal bovine serum (FBS). Functional expression of MRGPRX2 was assessed after 4 weeks via flow cytometry.

Airway Remodeling in Cystic Fibrosis Is Heterogeneous.

RATIONALE+OBJECTIVE/ Cystic fibrosis (CF) is characterized by bronchiectasis on imaging, while functionally evolving towards obstructive impairment. Despite its assumed importance in CF, small airway remodeling and its relation to bronchiectasis, is still poorly understood. METHOD/ On high-resolution computed tomography (HRCT, 600µm, CF=21, control=6) and micro-computed tomography (µCT, 150µm, CF=3, control=1) scans of inflated explant lungs, AV% (airway/total lung volume) was calculated as marker for bronchiectasis, while airway segmentation was used for generation analysis.