In utero and early-life nitrate in drinking water impacts lung function of weanling rats.

Consumption of nitrate in drinking water has previously been associated with a range of adverse health effects, including methemoglobinemia and potentially cancer. In animal models, it has been shown to impact respiratory structure and function, however, there is a paucity of data of the effects of in utero exposure on the respiratory health of offspring. In this study, pregnant rats were given drinking water containing nitrate at 50 or 100 mg/L (or control).

Elastic scattering spectroscopy for intraoperative oral cancer mucosal margin guidance: Initial results from a 104 patient cohort.

Objective: To assess Elastic Scattering Spectroscopy (ESS) classification accuracy of benign vs malignant tissue obtained during intra-operative oral cancer resection.

Methods: The study comprised 104 patients with a biopsy positive for oral cancer (N = 85) or dysplasia (N = 19) who were scheduled to undergo surgical excision. ESS measurements were obtained intraoperatively on and immediately adjacent to the lesion within the planned resection margin prior to excision, and on contralateral normal-site control tissue.

The Pre-Medical Health Coach (PHC) program: pre-medical students as volunteer health coaches at a safety-net hospital in California, 2016-2020.

Background: The volunteer Pre-Medical Health Coach (PHC) program engages student volunteers, in team-based primary care providing self-management support to patients with chronic conditions. Both the PHCs and the patients they serve are diverse. The aims of this study are to assess the impact of the PHC program on student outcomes and patient biomarkers.

Intracellular Pseudomonas aeruginosa persist and evade antibiotic treatment in a wound infection model.

Persistent bacterial infections evade host immunity and resist antibiotic treatments through various mechanisms that are difficult to evaluate in a living host. Pseudomonas aeruginosa is a main cause of chronic infections in patients with cystic fibrosis (CF) and wounds. Here, by immersing wounded zebrafish embryos in a suspension of P.