Publications by authors named "L J BEILIN"
Objectives: The relationship between nut intake and disability-free survival (healthy lifespan) in later life is unclear. The objective was to evaluate the association between nut intake and disability-free survival in a cohort of adults aged ≥70 years, and whether this varied according to overall diet quality.
Methods: This prospective cohort study involved 9916 participants from the ASPREE Longitudinal Study of Older Persons.
Background: The risk-benefit balance of statin use in healthy older people is uncertain. We describe the baseline characteristics of the STAREE (Statins in Reducing Events in the Elderly) trial, which is a randomized, double-blind, placebo-controlled trial among community-dwelling older people; the trial evaluated the effect of atorvastatin 40 mg for the prevention of major cardiovascular events (cardiovascular death, nonfatal myocardial infarction or stroke), and on disability-free survival (survival free of both dementia and persistent physical disability).
Methods And Results: STAREE enrolled people aged ≥70 years from 1583 general practices across Australia with no history of clinical cardiovascular disease, diabetes, or dementia.
Article Synopsis
- - This study analyzed how pregnancy complications and birth outcomes affect telomere length in children at age 17, using data from the Raine cohort study in Western Australia, which followed 2900 children over the years.
- - The research found no overall differences in telomere length based on individual maternal or birth outcomes, but females exposed to adverse conditions during pregnancy exhibited shorter telomeres compared to those born without complications.
- - Interestingly, while females from pre-eclamptic pregnancies specifically showed significantly shorter telomeres, no such effects were observed in males; this highlights the need for further studies to investigate the factors influencing telomere length in genders separately.
Article Synopsis
- This study explored the role of cytochrome-P450 eicosanoids, specifically 20-HETE and EETs, in regulating blood pressure and vascular stiffness among 1,054 young adults.
- Researchers found that higher plasma levels of 20-HETE were positively associated with increased systolic blood pressure and vascular stiffness measurements, even after accounting for other factors like sex and body mass index.
- The study concluded that 20-HETE significantly influences blood pressure and vascular health in young adults, while EETs did not show a significant impact in these areas.
Article Synopsis
- The study explored how slow gait speed and weak handgrip strength in older adults are linked to an increased risk of developing depression over time.
- It utilized data from a large group of participants (17,231) over approximately 4 years, measuring depression through a validated self-reported scale.
- Findings indicate that both low physical performance measures are significant risk factors for depression, suggesting the importance of addressing physical health to improve mental well-being in older adults.