Publications by authors named "L J Arnold"
Chronic muscle fatigue is a condition characterized by debilitating muscle weakness and pain. Based on our recent finding to study the potential effect of mTOR on ATG13 inactivation in chronic muscle fatigue, we report that biweekly oral administration with MHY1485, a potent inducer of mTOR, develops chronic illness in mice resulting in severe muscle weakness. As a mechanism, we observed that MHY1485 feeding impaired ATG13-dependent autophagy, caused the infiltration of inflammatory M1 macrophages (Mφ), upregulated IL6 and RANTES by STAT3 activation, and augmented demyelination in muscle-serving nerve fibers.
View Article and Find Full Text PDFBackground And Hypothesis: In accordance with the Cognitive Model of Negative Symptoms, defeatist performance beliefs (DPBs) are an important psychosocial mechanism of negative symptoms in schizophrenia-spectrum groups. DPBs are also mediators of negative symptom improvement in clinical trials. Despite the clinical significance of DPBs and their inclusion as a mechanism of change measure in clinical trials, the psychometric properties of the DPB scale have not been examined in any schizophrenia-spectrum group.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between the post-thaw morphology of cryopreserved equine IVP blastocysts and the likelihood of achieving pregnancy after transfer.
- The findings show that while the biopsy procedure before freezing does not negatively impact pregnancy outcomes, blastocysts with over 10% herniated cells post-thaw are less likely to result in pregnancy.
- Factors such as the interval between ICSI and blastocyst confirmation, and the specific stallion and mare involved, significantly influence pregnancy rates, with later developing embryos showing lower success rates.
α-Proteobacteria have been repeatedly isolated from marine sponges and proposed to be beneficial to the host. Bacterial motility is known to contribute to host colonization. We have previously identified pseudovibriamides A and B, produced in culture by Ab134, and shown that pseudovibriamide A promotes flagellar motility.
View Article and Find Full Text PDFObjective: To examine the association between childhood ADHD and lifestyle risk factors (physical inactivity and high fast-food consumption) from adolescence to early adulthood.
Methods: This retrospective cohort study used secondary data from Wave I to III of the National Longitudinal Study of Adolescent Health (Add Health) in a national representative sample of adolescents ( = 6,814). Multivariable Poisson regression and Generalized Estimating Equation were used to estimate adjusted relative risks (aRRs) and corresponding 95% confidence intervals (95% CIs), controlling for confounders.