Publications by authors named "L J Arend"
Introduction: Thrombotic microangiopathies (TMA) represent distinct pathological and clinical entities with known chronicity and recurrence. Kidney biopsy is the gold standard to diagnose TMA in patients with renal manifestations but the prognostic significance of acute or chronic phase of the disease has not been well studied. We examined the clinical characteristics, management, and predictors of acute vs.
View Article and Find Full Text PDFPurpose: To compare a novel high-resolution optical coherence tomography (OCT) with improved axial resolution (High-Res OCT) with conventional spectral-domain OCT (SD-OCT) with regard to their capacity to characterize the disorganization of the retinal inner layers (DRIL) in diabetic maculopathy.
Methods: Diabetic patients underwent multimodal retinal imaging (SD-OCT, High-Res OCT, and color fundus photography). Best-corrected visual acuity and diabetes characteristics were recorded.
Article Synopsis
- - A case of acute kidney injury related to high-dose methotrexate therapy in a patient with primary central nervous system lymphoma is presented, highlighting its rarity in such treatments.
- - The patient experienced high serum methotrexate levels shortly after the drug infusion, which led to the development of acute kidney injury, necessitating a kidney biopsy.
- - The biopsy revealed methotrexate crystals for the first time using toluidine blue staining and transmission electron microscopy, providing new insights into their ultrastructural characteristics.
Non-healing bone defects are a pressing public health concern accounting for one main cause for decreased life expectancy and quality. An aging population accompanied with increasing incidence of comorbidities, foreshadows a worsening of this socio-economic problem. Conventional treatments for non-healing bone defects prove ineffective for 5%-10% of fractures.
View Article and Find Full Text PDFArticle Synopsis
- - The optimization of electron microscopy (EM) tissue processing protocols is urgent due to the rising number of renal biopsies needing EM for accurate diagnoses, with traditional methods taking 48-52 hours compared to a faster 8-hour microwave-based method.
- - Concerns exist about the quality of the fast-processing EM (FEM) potentially affecting diagnoses; however, this study provides evidence that FEM produces comparably high-resolution images to the conventional EM (CEM).
- - Both prospective and retrospective analyses showed no significant differences between FEM and CEM in terms of image quality and structural features of kidney tissues, indicating that FEM can be a reliable alternative for quicker diagnoses.