Publications by authors named "L J Arcuri"
Immune reconstitution dynamics after unrelated allogeneic transplantation with post-transplant cyclophosphamide compared to classical immunosuppression with anti-thymocyte globulin: a prospective cohort study.
Haematologica
September 2024
Article Synopsis
- Post-transplant cyclophosphamide (PTCy) is important for the success of haploidentical stem cell transplants and also used with matched donors, but research on its effect on immune reconstitution is limited.
- A study compared immune recovery in patients receiving either anti-thymocyte globulin (ATG) or PTCy after unrelated donor hematopoietic stem cell transplantation, measuring immune cell counts at various time points.
- Results showed that ATG led to faster immune recovery initially, but by day 180, PTCy resulted in higher B cell counts, with specific T and NK cell subtypes associated with risk factors for acute and chronic graft-versus-host disease.
Long-Term Outcomes of Childhood Acute Lymphocytic Leukemia Treated with Adapted Berlin-Frankfurt-Münster (BFM) Protocols: A Multicentric Analysis from a Developing Country.
Cancers (Basel)
August 2024
Introduction: The objective of the current study was to determine the survival probabilities of children and adolescents with acute lymphocytic leukemia treated with adapted Berlin-Frankfurt-Münster (BFM) protocols and compare our results with the original BFM reports.
Methods: This retrospective study included 695 patients up to 19 years old treated with adapted BFM protocols between 1997 and 2018 in four hospitals in Rio de Janeiro. The 1997-2007 and 2008-2018 cohorts were analyzed separately.
Subcutaneous low-dose azacitidine as maintenance therapy following hematopoietic stem cell transplantation for acute myeloid leukemia and high-risk myelodysplastic syndrome-A propensity score matched analysis.
Hematol Transfus Cell Ther
December 2024
Objectives: To assess navigation accuracy for complete-arch implant placement with immediate loading of digitally prefabricated provisional.
Materials And Methods: Consecutive edentulous and terminal dentition patients requiring at least one complete-arch FDP were treated between December 2020 and January 2022. Accuracy was evaluated by superimposing pre-operative and post-operative cone beam computed tomography (CBCT), recording linear (mm) and angular (degrees) deviations.
Intensive salvage chemotherapy with VDTPACE or mCBAD followed by hematopoietic stem-cell support for refractory/relapsed multiple myeloma.
Eur J Haematol
October 2024
Introduction: Triple- and quad-refractory multiple myeloma patients usually have an aggressive course and a poor prognosis. Available therapeutic options are scarce.
Methods: The objective of the current study was to evaluate responses and toxicities of VDTPACE or mCBAD with hematopoietic stem-cell support as a bridge to subsequent therapies in patients with refractory/relapsed multiple myeloma.