Publications by authors named "L J Appel"

Background: Brain tumor in children can induce hemianopia, a loss of conscious vision, profoundly impacting their development and quality of life, yet no effective intervention exists for this pediatric population. This study aimed to explore the feasibility, safety, and potential effectiveness of a home-based audiovisual stimulation in immersive virtual-reality (3D-MOT-IVR) to improve visual function and functional vision.

Methods: In a phase 2a, open-labeled, nonrandomized, single-arm study, conducted from July 2022 to October 2023 (NCT05065268), 10 children and adolescents with stable hemianopia were enrolled to perform 20-min sessions of 3D-MOT-IVR every other day for six weeks from home.

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Many studies have implemented and evaluated task-sharing interventions with community health workers (CHWs) to manage hypertension. To identify gaps in research, we conducted a scoping review. We searched original articles published in PubMed and EMBASE between 2010 and 2022 and found 122 articles meeting our inclusion criteria.

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Introduction: Individuals with limb loss frequently report post-amputation phenomena, including nonpainful phantom sensations, phantom limb pain (PLP), and residual limb pain (RLP). Although post-amputation pain is common, not all patients benefit from widely accepted treatments. A greater understanding of phantom limb "telescoping", the experience of one's phantom hand or foot gradually approaching the residual limb, may assist in developing more effective interventions for reducing post-amputation pain.

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Article Synopsis
  • Wide pulse pressure (PP) is linked to increased risks of cardiovascular events and kidney failure, with every 10-mmHg increase in PP raising the risk of ASCVD events or death by 6% and kidney-related outcomes by 17% in individuals with chronic kidney disease (CKD).* -
  • The association between PP and health risks varies by age; younger individuals (ages 21-61) are more affected by cardiovascular events, while older individuals (ages 71-79) show a stronger link to kidney outcomes.* -
  • This study highlights that the underlying mechanisms connecting wide PP to negative health impacts differ by age, emphasizing the importance of considering age when assessing cardiovascular and kidney risks.*
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