Publications by authors named "L Izquierdo-Sanchez"
Background: Cholangiocarcinoma (CCA) represents a global health challenge, with rising incidence and mortality rates. This study aimed to elucidate the clinical course and practices of CCA in Latin America.
Methods: This observational cohort study investigated individuals diagnosed with CCA between 2010 and 2023 at five referral centres across Latin America.
Article Synopsis
- Metabolic liver disease is increasingly linked to hepatocellular carcinoma (HCC), but the molecular mechanisms remain poorly understood; this study focuses on DNA methylation's role in HCC associated with metabolic issues.
- The research involved 272 HCC patients and 316 control subjects, revealing 55 DNA methylation markers that effectively distinguished HCC cases from controls, achieving an AUC of 0.79 for accuracy.
- Combining these markers with demographic data improved sensitivity and specificity for identifying patients at risk for metabolic HCC.
Article Synopsis
- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious liver condition that includes simple fat buildup in the liver (steatosis) and can progress to more severe forms, like metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis, affecting over a third of the population.* -
- The causes of MASLD are complex and involve factors like metabolism, environment, genetics, gut microbiota, and dysregulated lipid levels that lead to harmful fat and cell stress.* -
- This review focuses on how lipotoxicity contributes to the development of MASLD, detailing important lipid types and their effects, and exploring potential therapies to improve lipid metabolism and reduce liver damage.*
Background: Resection of perihilar cholangiocarcinoma (pCCA) is a complex procedure with a high risk of postoperative mortality and early disease recurrence. The objective of this study was to compare patient characteristics and overall survival (OS) between pCCA patients who underwent an R1 resection and patients with localized pCCA who received palliative systemic chemotherapy.
Methods: Patients with a diagnosis of pCCA between 1997-2021 were identified from the European Network for the Study of Cholangiocarcinoma (ENS-CCA) registry.
Background And Aims: The mechanisms governing the progression of non-alcoholic fatty liver disease (NAFLD) towards steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remain elusive. Here, we evaluated the role of hsa-miRNA-21-5p in NASH-related hepatocarcinogenesis.
Methods: Hepatic hsa-miR-21-5p expression was evaluated in two cohorts of patients with biopsy-proven NAFLD (n = 199) or HCC (n = 366 HCC and n = 11 NAFLD-HCC).