Publications by authors named "L Ivanov"
Article Synopsis
- Lyme borreliosis, commonly known as Lyme disease, is a worldwide tick-borne infection caused by the Borrelia burgdorferi species, often starting with a distinctive erythema migrans rash at the bite site.
- Other skin symptoms may also appear initially, leading to potential misdiagnosis and treatment delays, highlighting the need for comprehensive evaluation of clinical findings, serology, and histology.
- A case of a 78-year-old woman revealed erythema nodosum as her initial manifestation following a tick bite; she was effectively treated with antibiotics and anti-inflammatory medications, and prescribed adjustments for her outpatient care.
Article Synopsis
- The contamination of various drugs with nitrosamines, which are linked to skin cancer, is becoming a growing concern, particularly in relation to keratinocyte cancer and drug-induced carcinogenesis.
- Nitrosamines can have both phototoxic and genotoxic effects, and the possibility of drug-induced skin cancer is heightened when multiple contaminated drugs are taken simultaneously, potentially activating oncogenes and deactivating tumor suppressor genes.
- A case study highlights a female patient who developed three basal cell carcinomas after being treated with contaminated medications, suggesting that such contamination could significantly contribute to skin cancer risk in polypharmacy.
Article Synopsis
- The mechanisms behind the development of skin tumors are still not fully understood, particularly regarding the roles of photosensitivity and phototoxicity.
- Recent studies have linked specific nitrosamines, contaminants in common pharmaceuticals, to gene and phototoxicity in humans, raising concerns about their potential carcinogenic effects.
- Long-term use of contaminated medications may contribute to skin cancer risk by interfering with tumor suppressor genes and activating oncogenes, affecting overall cancer development.
Despite the fact that the pathogenesis of cutaneous melanoma is shrouded in mystery, factors that have been neglected or unnoticed until now have come to the attention in recent years, and in all likelihood, they could also be pivotal. These factors, known as nitrosamines or NDSRIs, are characterized by high carcinogenic and mutagenic potency, and some of them have demonstrated these properties to human DNA as well. Unfortunately, these ingredients also turn up as contaminants in about 300 of the most widely distributed drugs worldwide.
View Article and Find Full Text PDFTwo steps are able to lead to a significant decrease in the incidence of skin cancer overall and/or to its parallel and successful surgical treatment. The first step concerns its non-occurrence or less frequent clinical manifestation and is largely related to the modern concept known as prevention, but not the one mainly related to solar radiation, but: 1) informing patients about the possible contamination of certain drugs with carcinogens/nitrosamines/NDSRIs and 2) making clinicians aware of the modern concept of limited to completely eliminated intake of nitrosamines/NDSRIs in medications. The ineffectiveness of either of these entities could in all likelihood be seen as one of the major causes of the headline growth in the incidence of skin cancer and keratinocytic cancer in particular.
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