Publications by authors named "L Iu Lukhnova"
Article Synopsis
- Tularemia in Kazakhstan is influenced by its landscape and geography, particularly due to rodents and ectoparasites that carry the disease.
- A retrospective study from 2000 to 2020 examined the spatial and temporal characteristics of tularemia, including outbreaks, infection sources, and transmission factors.
- Over 600 strains were collected from rodents and ticks, identifying active tularemia foci in several regions while noting low-activity areas, with no cases reported in Mangystau and Turkestan regions.
This article describes strains isolated in Kazakhstan since the 1950s until year 2016 from sixty-one independent events associated with anthrax in humans and animals. One hundred and fifty-four strains were first genotyped by Multiple Locus VNTR (variable number of tandem repeats) Analysis (MLVA) using 31 VNTR loci. Thirty-five MLVA31 genotypes were resolved, 28 belong to the A1/TEA group, five to A3/Sterne-Ames group, one to A4/Vollum and one to the B clade.
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- Tularemia, caused by the bacteria Francisella tularensis, is a dangerous zoonotic infection, and the study aimed to analyze the strains present in Kazakhstan using advanced genetic techniques like whole genome sequencing (WGS) and MLVA.
- The research involved genotyping 38 isolated strains from various sources, including water bodies and wildlife, categorizing them into two F. tularensis holarctica lineages (B.4 and B.12), and successfully developing a multiplex PCR assay to identify specific genetic markers.
- The study found that strains with identical MLVA genotypes were consistent across different methods, and comparisons revealed that variations in genotypes existed over long timeframes and distances, suggesting that migratory birds may play
Article Synopsis
- - The study investigates two anthrax outbreaks in western Kazakhstan from 2009 that occurred in the same location and timeframe near major roads, suggesting a potential single source of infection.
- - Various genetic analyses, including MLVA and CanSNP, were conducted to differentiate between the strains involved in the outbreaks.
- - Findings revealed that despite the close timing and location, the outbreaks were genetically distinct and not linked to the same source of infection.
subsp. is the least studied among the four subspecies. We present here the genome data of subsp 240, isolated in the southern region of Kazakhstan.
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