[Contrary action of khingamin on the rejection of a skin allograft and on the level of antibody-producing cells in mice].

The effect of antimalarial drug khingamin preinjection on skin allograft rejection and the level of antibody forming cells (AFC) in Jerne reaction has been investigated. The drug at the doses of 30, 40, 50 mg/kg inhibited skin allograft rejection. The dose of 20 mg/kg proved ineffective.

[Effect of khingamin on the development of SV40 virus-induced and transplantable tumors in hamsters].

Chloroquine was administered to 2-month hamsters inoculated at birth with an oncogenic virus SV-40 which was injected daily in a dose of 30 mg/kg for a month. Chloroquine-treated animals showed a statistically significant (6 weeks) shorter latent period of tumour development. The drug exerted no effect neither on the rate and incidence of transplantable E-1 test tumours or on the phenomenon of resistance in experiments on 4-6-month hamsters under its multiple administration in doses close to maximum tolerated ones (40 mg/kg).