Hemopoietic stem cell transplantation using mouse bone marrow and spleen cells fractionated by lectins.

Mouse bone marrow and spleen cells were fractionated with the aid of soybean agglutinin and peanut agglutinin. A test for spleen colony-forming units in the isolated fractions showed that the hemopoietic stem cells are agglutinated by both of these lectins. The capacity of the agglutinated fractions to reconstitute lethally irradiated allogeneic mice was investigated.

The acute effects of various cytotoxic compounds injected into the prostate glands of dogs.

The acute effects of direct injections with various cytotoxic compounds into the prostates of adult dogs were studied microscopically. The effects remained localised to the site of injection, with no diffusion of the agents into other areas of the prostate. No systemic effects were observed despite the high concentrations used.

Intraprostatic Injections of various antitumour compounds into rats: Part II. Chronic effects.

Histopathological studies were carried out at intervals of one, two and three months after a single injection of one of seven antitumour compounds into the prostates of adult male CR rats. The histological findings indicate mainly a long term effect of the compounds tested on the glandular epithelium of the rat prostate. The effect is strictly local and no side effects were seen.