Publications by authors named "L Ikeda"
Article Synopsis
- Cerebrospinal fluid (CSF) is vital for brain health, providing nutrients, signaling, and removing toxins while supporting brain development and function.
- The study examined folate transport in CSF, focusing on key proteins that move folate from blood into CSF and then into brain cells, linking folate status to neurological conditions with ventricular enlargement.
- Findings indicate that various neurological conditions show distinct folate imbalances, suggesting that addressing these imbalances could help alleviate symptoms and deficits related to these conditions.
Article Synopsis
- Effective detection of SARS-CoV-2 variants through wastewater analysis can complement existing clinical testing methods, especially in resource-limited areas where traditional testing may be biased.* -
- The study implemented improved virus concentration techniques and software to enhance the sequencing of multiple virus strains from wastewater, resulting in high-resolution data over 295 days at a university and its surrounding county.* -
- Wastewater surveillance identified emerging variants up to 14 days earlier than clinical methods and revealed instances of virus spread that clinical testing missed, highlighting its potential for public health monitoring.*
As SARS-CoV-2 continues to spread and evolve, detecting emerging variants early is critical for public health interventions. Inferring lineage prevalence by clinical testing is infeasible at scale, especially in areas with limited resources, participation, or testing/sequencing capacity, which can also introduce biases. SARS-CoV-2 RNA concentration in wastewater successfully tracks regional infection dynamics and provides less biased abundance estimates than clinical testing.
View Article and Find Full Text PDFObjectives: We sought to evaluate opioid prescribing in an ambulatory setting among patients with noncancer chronic pain (CP).
Study Design: Cross-sectional analysis.
Methods: We identified patients with at least 2 CP encounters at least 30 days apart in 2012 in the electronic health records of a community-based healthcare delivery system in northern California.