Retrospective assessment of clonal origin of cell lines.

Cell lines used for the manufacture of recombinant proteins are expected to arise from a single cell as a control strategy to limit variability and ensure consistent protein production. Health authorities require a minimum of two rounds of limiting dilution cloning or its equivalent to meet the requirement of single cell origin. However, many legacy cell lines may not have been generated with process meeting this criteria potentially impeding the path to commercialization.

[Guidelines for comprehensive assessment of educational and training conditions of children and adolescents].

General guidelines have been developed to make a comprehensive assessment of the conditions of education and teaching and to predict probable changes in preschool- and schoolchildren's health. The guidelines envisage the use of standard procedures and programmes for the assessment and optimization of educational and teaching conditions for children and adolescents in educational establishments of different types.

[The system of continuous postgraduate education of public health physicians and its optimization].

The paper describes the system of continuous post-graduate advanced training proceeding from the example of physicians who participated in the training course at the chair of child and teenage hygiene at the Central Institute for Advanced Medical Studies during correspondence and full-time training travelling cycles. The work was conducted with the group of physicians (153 persons), participants of the experimental group--15 physicians from the city of Yaroslavl and Yaroslavl region. The targeted training was carried out in the form of post-cycle training: subject studies, consultations and seminars conducted by the statt of the chair, performance of scientific and practical work, etc.

[Status and prospects of the development of postgraduate training of public health physicians in child and adolescent care].

The state and dynamics of postgraduate education of sanitary physicians and their assistants on child and adolescent hygiene were analyzed during 1972-76 and 1982-86 in the Soviet Republics and the USSR in general. Causal and effective relationships of the detected drawbacks were established and ways of their elimination according to the restructuring of the system of refresher courses in public health presented.