Burden of Atrial Fibrillation and Atrial Flutter From 1990 to 2021 in China: Global Burden of Disease Study 2021 Update.

Background: Atrial fibrillation (AF) and atrial flutter (AFL) represent increasingly significant health burden globally. We aimed to systematically evaluate the status and trends of AF/AFL burden and attributable risk factors in China.

Methods: We assessed the burden of AF/AFL measured as prevalence, incidence, mortality, and disability-adjusted life years (DALYs), by sex and age groups in China based on the Global Burden of Diseases Study (GBD) 2021 project.

The Metabolic and Physiological Responses to Spaceflight of a Lipopeptide-Producing Bacillus subtilis.

Outer space is an extreme environment and the survival of many microorganisms after spaceflight is well established. However, adaptations of Bacillus subtilis to space stress, particularly metabolism, are largely unknown. Here, we first performed a spaceflight mission of the B.

Consistency assessment of tissue-level brain injury criteria in FEHM.

Tissue-level brain injury criteria are essential for analyzing brain injuries using finite element head models (FEHMs), but their consistency remains unclear. This study applied the data-driven method previously proposed for maximum principal strain (MPS) injury criterion to determine thresholds for von Mises stress (VMS), pressure, maximum shear stress (MSS), and the rate of MPS. It then assessed the consistency of these criteria in terms of injury status, injury location, and injury overlap rate in 18 impact simulations.

Intermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate.

Platelet hyperreactivity contributes significantly to thrombosis in acute myocardial infarction and stroke. While antiplatelet drugs are used, residual ischemic risk remains. Intermittent fasting (IF), a dietary pattern characterized by alternating periods of eating and fasting, has shown cardiovascular benefits, but its effect on platelet activation is unclear.

Unleashing the power of peptides in prostate cancer immunotherapy: mechanism, facts and perspectives.

Prostate cancer, the second most common cancer in men, often progresses to castration-resistant prostate cancer despite androgen deprivation therapy. Immunotherapy, revolutionary in cancer treatment, has limited efficacy in prostate cancer due to its "cold tumor" nature. Peptides, with unique advantages, offer new hope.