Efficacy of luteolin on the human gastric cancer cell line MKN45 and underlying mechanism.

Objective: To investigate the antitumour efficacy of luteolin on gastric cancer (GC) and study the mechanism underpinning the action.

Methods: Effects of luteolin on cell growth inhibition, apoptosis, and cell cycle arrest in MKN45 cells were investigated using the cell counting kit-8 assay. Changes in the mitochondrial membrane potential after luteolin treatment were assessed using 5,5',6,6'-tetra-chloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanineiodi-de (JC-1) staining.