Quantitative analysis of SLC34A2 expression in different types of ovarian tumors.

Aim: The main purpose of this study was to estimate the SLC34A2 gene expression in normal ovary and different types of ovarian tumors.

Methods: We have investigated SLC34A2 gene expression level in papillary serous, endometrioid, unspecified adenocarcinomas, benign tumors, and normal ovarian tissues using real-time PCR analysis. Differences in gene expression were calculated as fold changes in gene expression in ovarian carcinomas and benign tumors compared to normal ovary.

Vascular endothelial growth factor exression in uterine cervical cancer: correlation with clinicopathologic characteristics and survival.

Aim: This retrospective study was performed to determine the vascular endothelial growth factor (VEGF) expression in cervical cancer cells, and to examine its correlation with clinicopathologic characteristics and survival of patients.

Methods: Seventy-five paraffinembedded primary tumors were stained immunohistochemically for VEGF expression, which was analysed semiquantitatively.

Results: The significant correlation between VEGF expression and stages of disease, as well as pelvic lymph node metastasis was observed.

The study of phosphate transporter NAPI2B expression in different histological types of epithelial ovarian cancer.

Unlabelled: The identification of markers that are specifically expressed by different histological types of epithelial ovarian cancer (EOC) may lead to the development of novel and more specific diagnostic and therapeutic strategies. Sodium-dependent phosphate transporter NaPi2b (or MX35 ovarian cancer antigen) is a novel perspective marker of EOC. To date, the studies on NaPi2b/MX35 expression in different histological types of EOC are limited.

The sensitivity of chemioresistant human tumor explants to lysis by activated and nonactivated autological lymphocytes: a pilot study.

Aim: The comparative study of antitumor action of peripheral blood lymphocytes (PBL) and lymphokin-activated killer cells (LAK) on autologous cell of chemoresistant and chemosensitive human soft tissue sarcomas and tumors of epithelial origin.

Materials And Methods: Tumor explants (15 samples of soft tissue sarcomas, 10 samples of cervical and ovarian carcinomas) were cultivated with autologous lymphocytes in double diffusion chambers. Evaluation of the results was done on the basis of morphological criteria of explants growth.