A study of the functional state of the pressor sympathetic-adrenal and renin-angiotensin-aldosterone systems in 112 patients with rheumatic heart disease associated with systemic arterial hypertension indicates that changes in the activity of pressor humoral systems depended on the pathogenetic form of arterial hypertension, phase of arterial hypertension and severity of hemodynamic disorders. These was a close correlation between the excretion of noradrenalin, plasma renin activity and aldosteron concentration indicating that these two humoral systems change in the same direction and confirm their undoubted participation in the pathogenesis of arterial hypertension in rheumatic heart disease.
View Article and Find Full Text PDFA study of 115 patients with rheumatic heart disease associated with arterial hypertension revealed significant changes of functioning of depressor kallikrein-kinin system of the kidneys and blood. The period of formation of arterial hypertension is already distinguished by an exhaustion of the depressor systems manifested in a marked reduction of the kallikrein excretion in response to physical loads and a reduction of the extracellular volume deteriorating in the course of stabilization of arterial hypertension.
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