[Clinico-biochemical study of epileptic children and adolescents and their relatives].

The observations were convened in the framework of clinico-genetical study of epilepsy. It was established that in the blood serum of epileptic children and adolescents and their relatives there is an increase of general activity of LDH. With the aid of electrophoresis in agar and polyacrylamid gel it was possible to show an increase in the content of LDH-1 and a drop in LDH-3.

[Alterations in the activity of lactate dehydrogenase and its isoenzyme spectrum in the blood of patients with epilepsy].

The paper is concerned with the general activity of LDH and the spectre of its isoenzymes which was determined by different techniques in the blood serum of adult epileptic patients, epileptic children and adolescents between seizures, as well as in adult patients during and at different periods after covulsive fits. It was established that the general activity of LDH and the percent content of isoenzymes LDH-I in the blood serum of adult epileptic patients is less compared to epileptic children and adolescents and normals. During convulsive fits the general activity of LDH and LDH-I in the blood serum increases, which is indicative of an intensification of glycolytic processes.