[Monitoring for Neisseria meningitidis species using sequencing of variable fragments of surface proteins FetA and PorA genes].

Aim: To perform advanced antigenic characterization of meningococci belonging to serogroups A and B and circulating in Moscow according to modern nomenclature of Neisseria meningitidis strains.

Materials And Methods: Method of typing of "VR" fragment of FetA protein together with methods of genetic subtyping and multilocus sequence typing was used.

Results: Detailed information about studied strains was inputed in Internet database--http://pubmlst.

[Single-stranded DNA modification by an oligonucleotide-phthalocyanine Fe(II) conjugate: kinetic regulation and mechanism].

Catalytic oxidative modification of single-stranded DNA with hydrogen peroxide and molecular oxygen in the presence of a conjugate containing an oligonucleotide complementary to the DNA fragment and tetra-4-carboxyphthalocyanine Fe(II) was studied. The conjugate examined was found to be active in the reaction of oxidative DNA cleavage in the presence of hydrogen peroxide, like earlier studied oligonucleotide conjugates containing tetra-4-carboxyphthalocyanine Co(II) and 2,4-di-[2-(2-hydroxyethyl)]deuteroporphyrin IX Fe(III) metallocomplexes generating active oxygen forms. The new conjugate was more active in the case of oxidation with molecular oxygen.