A novel technique for studying the effects of technologically processed antibodies by evaluating the rate of oxidation of ascorbic acid during the reduction of the green-blue ABTS + radical.

Since the pharmaceutical market is developing, there is a need for novel techniques for determining the physical-chemical properties of drug solutions. Drugs based on technologically processed antibodies (TPA) are an example of compounds that require a methodology for studying their effects. It has been shown that the process of external impacts during the manufacture of TPA-based drugs can induce breaking of intermolecular and intramolecular bonds in the solvent molecules, providing the emergence of new bonds with the molecules of the substance used for the manufacture of an active pharmaceutical ingredient.

[Clinical guidelines «Precocious puberty»].

The precocious puberty is an urgent problem of pediatric endocrinology characterized by clinical and pathogenetic heterogeneity. The appearance of secondary sex characteristics before the age of 8 years in girls and 9 years in boys requires timely diagnosis and the appointment of pathogenetically justified treatment in order to achieve the target indicators of final growth and prevent social deprivation. The developed clinical guidelines are the main working tool of the practitioner.

Spectral-Luminescent and Electroluminescent Properties of Charge-transfer Systems Based On Electron-donating Diphenylamine Derivatives and Acceptors of Dibenzothiophene Sulfone and Phenanthridine.

Spectral characteristics and luminescence under the photo- and electro-excitation of substituted dibenzthiophene sulfone and phenanthridine were studied in this paper. Diphenylamines are substituents introduced in the 2nd and 7th positions (linear configuration) or the 3rd and 6th positions (angular configuration) of dibenzthiophene sulfone or phenanthridine. All molecules show delayed fluorescence, both in solutions and films produced by thermal vacuum deposition.

[The differential diagnosis of constitutional delay of puberty and hypogonadotropic hypogonadism in boys].

Background: The problem of differential diagnosis of constitutional delay of puberty/CDP and hypogonadotropic hypogonadism/HH in boys is discussed, as boys have similar genetic mechanisms and appearance.

Aims: to determine accuracy of the criteria for the differential diagnosis of CDP and HH.

Materials: The study included 56 boys 14.

Luminescent Properties of Zn and Mg Complexes on N-(2-Carboxyphenyl)salicylidenimine Basis.

New zinc and magnesium complexes of N-(2-carboxyphenyl)salicylidenimine) were synthesized and structurally characterized by elemental analysis, FT-IR, and X-ray single-crystal analysis. These complexes exhibit tuneable luminescence in the solid state from blue to green by varying by metal ion and composition. Moreover, the quantum yields range from 0.