[Stress and the thyroid gland].

The review highlights the effects of acute and chronic stress on thyroid metabolism. Special attention is paid to the influence of stress and the direct effects of glucocorticoids on the thyroid status, the activities of thyrocyte iodine uptake, oxidation and organification as well as peripheral metabolism of thyroid hormones (deposition and transport of thyroid hormones, deiodinase activities in different tissues). The role of stress in the development of thyroid pathology is analysed and characteristic features of thyroid function alterations during impaired functioning of the pitiutary-adrenal system are established.

[Iodide metabolism in the rat thyroid at early and remote periods following the long-term exposure of external fractionated gamma-radiation].

The research was made into the effects of 20-fold exposure to external gamma-radiation (0.1-0.5 Gy) on the activities of the key steps of iodide metabolism (absorption, oxidation and organification) in the rat thyroid as well as on its morphologic structure at the early (1 day) and remote (30 and 180 days) periods after the radiation.

[The effect of long-term external ionizing radiation on the functional activity of rat thyroid under enhanced potassium iodide consumption].

The study was devoted to the effect of long-term (20 days) external ionizing radiation at a dose of 0.5 Gy on the iodide metabolism in the rat thyroid under supplementation of high iodine doses (10 daily KI doses). It was found that the potassium iodide administration partially prevented the effects of a post radiation decrease of serum thyroid hormone levels (the level of T4 was normal and that of T3 was 77.

[Antioxidant system activities and lipid peroxidation in nodal and non-nodal thyroid tissue of patients operated in connection with euthyroid nodular goiter].

The activities of the antioxidant systems (AOS) and lipid peroxidation (LP) were studied in the thyroid (operation material) of patients with euthyroid nodular goiter (in carcinoma, adenoma, colloid goiter tissues as well as in non-nodular adjacent thyroid tissue). Increased activities of superoxide dismutase (SOD, by 101.0 and 125.

[Effects of chronic administration of high doses of potassium iodide on iodine metabolism in the rat thyroid gland].

The effect of various doses of KI on iodine methabolism in rat thyroid gland was investigated. Treatment with 1, 3, 10, 100 and 500 physiological daily doses of KI for 14 days had no influence on blood level of thyroid hormones. However, increased administration of KI was accompanied by the increase of iodine in the thyroid gland tissue by 60-121% due to 35-108% and 94-128% increases of protein-bound and free fractions respectively.