[Several indicators of lipids, blood hormones and T-cell unit of the immune system in mice with increased body mass at distant periods after local irradiation of the thymus, hypothalamus-hypophysis and gonads].

In hybrid mice it was shown that the local irradiation of zones of thymus, hypothalamus-hypophysis (0.5, 1 and 10 Gy in both cases) and gonads (10 Gy) resulted in significant increase in weight at long terms after irradiation. In animals with increased weight the amount of lipids raised, balance of hormones and state of thymus-dependent unit of immune system changed, and exterior symptoms of early aging were observed.

[Free radical lipid peroxidation in clean-up workers from the Chernobyl nuclear reactor accident depending on working conditions in the area of radioactive contamination].

Plasma lipids and antioxidant defense factors were examined 5-6 years after the exposure in 49 subjects who had taken part in decontamination of the territories after the Chernobyl accident against those in non-exposed donors. Elevated levels of heptane-soluble lipoperoxides and of dienketones were registered, though malonic dialdehyde changed little. The above parameters deviated from the control level more in subjects exposed to higher ecological risk.

[Mechanisms of the effect of general anesthesia with barbiturates on immunity].

The effect of short-acting barbiturates on the number of theophylline-resistant and theophylline-sensitive T-lymphocytes in donors and patients with lung cancer on the function of spontaneous and induced donor regulators as well as the concentration of cyclic nucleotides and T-lymphocytes in donors has been studied in vitro. The effect of general anesthesia with barbiturates on the number of lymphocyte populations and subpopulations in the peripheral blood of somatically healthy patients with minimum surgical trauma has also been assessed. These studies as well as previous investigations serve the basis for elucidating the impact of general anesthesia with barbiturates on the immunity.

[A method of modified neuroleptanalgesia in lung surgery].

A modification of neuroleptanalgesia (NLA) has been developed to be applied in operations on the lungs. It is based on the inclusion of indomethacin and diazepam into premedication, on the bolus administration of phentanyl, droperidol, and diazepam prior to the most traumatic stages of the operation, and on the subsequent infusion of phentanyl and droperidol. The modified technique of NLA has been applied in operations on 19 patients with lung cancer.