Role of gut microbiota and fecal metabolites in the protective effect of soybean pulp-rich diet against estrogen-induced cholestasis in rats.

This study was designed to explore the role of gut microbiota and its metabolites in the treatment of estrogen-induced cholestasis (EIC) in rats with a soybean pulp-rich diet and to clarify the effects of daidzein (DAI), a principal active ingredient of soybean pulp. The findings demonstrated that the soybean pulp-rich diet could relieve cholestasis by decreasing the levels of total bile acids (TBA) and alkaline phosphatase and enhancing the bile flow rate. Through gut microbiota and metabolomics analyses, it was revealed that this diet might alter the abundances of certain bacterial taxa including , , and , thus influencing lipid metabolism, tryptophan metabolism, and steroid metabolism, which led to disparities between the groups fed with and without the soybean pulp-rich diet.

Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003-2023).

Background: Glioma is the most aggressive primary malignant tumor of the central nervous system, characterized by high recurrence rates and resistance to chemoradiotherapy, making therapeutic resistance a major challenge in neuro-oncology. Recent research emphasizes the role of the tumor microenvironment (TME) and immune modulation in glioma progression and resistance. Despite these advances, a comprehensive bibliometric analysis of research trends in glioma chemoradiotherapy resistance over the past two decades is lacking.

Energy consumption and environmental impact analysis of biomass graded deconstruction activation catalytic deoxygenation for rich single-ring aromatic bio-oil preparation.

The graded deconstruction activation catalytic deoxygenation (GDACD) technology positively influenced biomass pyrolysis product quality, but the energy consumption and environmental impact for industrial applications were still uncertain. To realize the requirement of biomass conversion for high energy efficiency and low environmental impact, this study developed a poly-generation system of GDACD, syngas combustion, and waste energy power generation to produce high-quality oil with a high content of single-ring aromatic and industrial steam. The poly-generation system was investigated and evaluated according to the energy and exergy balance and environmental pollutant emissions.

Preparation of flavonoids from and evaluation of their antioxidant and α-glucosidase inhibitory activities.

is an important homologous medicinal and food plant, and its fruit is rich in flavonoids. However, few studies have reported the preparation and bioactivity of flavonoids in (ATF). In this study, the optimal conditions for ultrasound-assisted extraction of ATF were identified through response surface optimization.

The metal-support interactions of Cr(OH) enhance the performance of supported Au-based benzyl alcohol electrooxidation catalysts.

An Au-based heterojunction electrocatalyst supported on Cr(OH) was synthesized by a liquid-phase method. The metal-support interactions between Au and Cr(OH) play a key role in modulating the microstructure and charge distribution of the Au-based active centers. This synergy significantly enhances the catalytic activity and stability for the electrooxidation of benzyl alcohol.