[Disorders of purine metabolism in patients with peritonitis complicated by sepsis].

Progressive hypoxia and cell destruction leading to increased production of active oxygen forms by xanthinoxidase and manifesting by an increased level of uric acid in the blood in parallel with inhibited pentose cycle reaction due to low activity of glucose-6-phosphate dehydrogenase determine the severity of peritonitis.

[Cellular factors of natural immunity in patients with acute peritonitis].

A total of 233 patients with acute peritonitis who in the postoperative period were subjected only to conventional complex intensive care (Group I) have been examined. Changes in medium molecular weight polypeptide level, relative and absolute monocyte and granulocyte content, phagocyte number and index, blood phagocytosis capacity and metabolic potential of macrophages in spontaneous and activated NBT test have been established. Integral tetrazolium neutrophil activity was different in subgroups of patients with (Group I) and without (Group II) complications.

[The general biological principles of the development of complications in the postoperative period of acute peritonitis and the expediency of hemosorption].

The dynamic study of a number of clinical and laboratory findings in 107 patients with acute peritonitis have shown that with the current complex infusion therapy the onset of postoperative complications is to a great extent mediated by high toxin level--medium molecular mass polypeptide, inhibiting the processes of protein synthesis and consequently causing changes in the relationship between adaptation compensatory reactions, which demonstrates the necessity of additional active detoxicating therapy, i.e. hemosorption (HS).

[Immunologic effect of hemosorption in patients with acute peritonitis].

An examination of 65 patients with acute diffuse peritonitis has shown that pronounced T-immune deficiency is observed in the postoperative period of acute peritonitis. Hemosorption was shown to be efficient in patients with high content of toxin which allows considering the method of extracorporeal detoxication as effective means of immune-correcting therapy in peritonitis patients with high level of toxinemia who make up a group of risk.

[Extracorporeal detoxification of the body and the B system of immunity in acute peritonitis].

65 patients with acute peritonitis of various etiology have been examined. It has been established that marked toxemia in the early postoperative period, normal relative B-lymphocyte content, low level of EAC-RFC with moderate to high content of receptors to sheep red blood cells are prognostically unfavourable. The level of intermediate molecular mass polypeptides (IMMP) above 0.