Markers of hepatitis E among the population of the Greater Sochi and in monkeys of the Adler primate center.

Serum from humans (n = 646) and monkeys (n = 1867) collected during the period 1999-2013 was tested by enzyme immunoassay. Anti-HEV IgG was detected significantly more frequently (P ≥ 0.001) in rhesus macaques (Macaca mulatta) - 45.

[Hepatitis E virus antibodies in the macaques and in the personnel serving the macaques of the Adler apery].

There is evidence for the rather high detection rate of antibodies against hepatic E virus (HEV) was rather high in the macaques from the Adler apery in 1999-2005. Anti-HEV was detected in 232 (57.3%) out of 405 examined rhesus macaques (Macaca mulata) and in 16 (16%) out of 100 Java ones (M.

[Secondary infection with hepatitis A in Rhesus monkeys after experimental inoculation].

Time course of specific humoral immunity is studied in 186 Macaca mulatta spontaneously infected with hepatitis A virus (HAV). Immunity parameters are characterized quantitatively and qualitatively and their similarity to those in human hepatitis A (HA) is demonstrated. Repeated HA was reproduced in 12 seropositive Macaca mulatta infected with HAV-MR in high doses.

[Characteristics of experimental models of hepatitis A in Papio hamadryas].

Hepatitis A (HA) was induced in 14 Papio hamadryas by strain VHA-PH isolated from this species of monkeys with spontaneous infection, strain VHA-MM isolated from Macaca mulatta, and a unique strain VHA-H3 isolated from a patient; this latter strain is pathogenic for Macaca mulatta in experiment. All infected seronegative animals developed a disease with virological, serological, biochemical, and morphological signs characteristic of human HA, but the duration of these signs manifestation varied. Virus in the feces and an increased level of SGPT were detected periodically starting from days 3-26 to 24-135, and in 4 monkeys even later (up to days 163-238).

[Preparation and characteristics of cultured strains of hepatitis A virus from humans and monkeys].

Cultural strains of hepatitis A virus (HAV) have been isolated from spontaneously infected Macaca mulatta (HAV-MM), Papio hamadryas (HAV-PH), African green monkeys Cercopithecus aethiops (HAV-CA), and patients (HAV-H). The strains replicate in continuous cells lines AGMK, 4647, Vero, and FRhk-4. AGMK and 4647 cells are the most permissive at 32 degrees C.