[Blood DNA Radiosensitivity May Be Predictive Marker for Efficacy of Radiation Therapy in Glioma Tumorbearing Individuals].

Animal and clinical studies were conducted to evaluate the association between the blood DNA radiosensitivity, assessed by determining the original S-index ex vivo, and the response of gliomas to irradiation in vivo. Possible modifications of the latter after administration of iron-containing water (ICW) in rats were also explored. The study was performed on the rats with subcutaneously implanted experimental glioma-35.

[Possibilities of ultrasound examination with elastography in the diagnosis of recurrent rectal cancer].

The purpose of this study was to evaluate possibilities of complex ultrasound examination in the diagnosis of recurrent rectal cancer. The study included 40 patients with recurrent rectal cancer, 19 men and 21 women aged from 27 to 83 years, mean age was 60 +/- 7.9 years.

[Immediate results of combined therapy for local recurrences of rectal cancer].

The purpose of this paper was to increase the effectiveness of radiation therapy (RT) of local recurrence of rectal cancer (MRRPK) by setting the preferred modes and dynamic medium dose fractionation irradiation MRRPK, assessing immediate outcomes, identifying the frequency and severity of early radiation reactions during radiation therapy. The study included 60 patients with a diagnosis of "local recurrence of rectal cancer." The median age was 67 years.

[Personalized treatment of tumor-bearings after prediction of radio and chemoradio-therapy efficacy by means of blood DNA radiosensitivity].

Ongoing studies on the tumor and non-tumor samples carried out worldwide give evidence that some apoptotic indexes, DNA-based microarray molecular profiling analysis as well as determination of single nucleotide polymorphisms in the genome of a patient's tumor can serve perspective markers of radiosensitivity for the response prediction in individual patients to intendedradiation therapy. Over the last years there has been an increasing interest in radiogenomic and characterization of DNA array molecular profiles that can predict the response to irradiation in tumor and non-tumor tissues. Now a technology of the short-term and inexpensive determination of indices aimed at an objectively based use of radiation therapy in experiment or clinic after evaluation of blood DNA radiosensitivity has been developed.

[Predicting of the effectiveness of radiotherapy and chemoradiotherapy for cancer patients].

Studies carried out on samples of tumor and non-tumor tissue indicate that markers of radiosensitivity for predicting individual patient response to the planned radiation therapy may be the indicators of apoptosis and molecular profiles read from the DNA of patients. At present there is developed a technology for rapid and economical determining of indicators for the reasonable use of radiation therapy in the radiological practice in patients with breast cancer, bladder cancer and malignant glioblastomas by means of an evaluation of radiosensitivity of the DNA of blood.