[Neuroendocrine aspects of the pathogenesis and treatment of disseminated sclerosis and lateral amyotrophic sclerosis].

Comparative study of neurologic, immunologic, and endocrinologic signs of disseminated sclerosis and lateral amyotrophic sclerosis was carried out by radioimmunoassay, monoclonal antibodies, and microcytotoxic Terasaki's test. The data have shown a tendency to hyperthyroid and hypocorticoid states in 60 percent of lateral amyotrophic sclerosis patients. Fluctuations in hormonal levels of disseminated sclerosis patients were quite the opposite in 37.

[Aldosterone content of the blood and tissues in rats with an altered level of adrenergic activity].

The content of aldosterone (A) was studied in rat adrenal glands, blood plasma and peripheral tissues--in the myocardium, skeletal muscles, thymus and liver--1 h after the administration of alpha-adrenergic stimulator noradrenaline and beta-adrenergic stimulator isoprenaline and after simultaneous administration of alpha- and beta-blockers and a sympatholytic agent (pyrroxan, propranolol and bretylium tosylate respectively). Adrenergic stimulation did not change the level of A in the adrenal glands, raised its blood concentration and, to a greater extent, its level in the peripheral tissues. A marked increase in the blood concentration of A resulted from isoprenaline and its accumulation in tissues--from noradrenaline.

[Hypophyseal-adrenal system function in disseminated breast cancer].

The functional condition of the pituitary-adrenal system was studied in 94 patients with disseminated breast cancer. A decreased excretion of 17--OCS's with urine and an increased cortisol level in blood were observed. This was interpreted as relative (extra-adrenal) failure of pituitary-adrenal function in breast cancer patients.