Publications by authors named "L I Huihui"
Background: Lymphocyte migration plays a key role in the development of acute graft-versus-host disease (aGVHD). Blocking lymphocyte migration by targeting chemokine receptors, such as CXCR3, may be a promising strategy for preventing and treating aGVHD. Our previous studies have shown that short-term CXCR3 antagonist treatment combined with cyclosporine A alleviated aGVHD.
View Article and Find Full Text PDFObjective: To study the effect of Jiangzhi Xiaoban tablet (, JZXB) on toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB)/Nod-like receptor protein 3 (NLRP3) signaling pathway expression in atherosclerosis (AS) mice by establishing a mouse model of AS, and to explore its mechanism of prevention and treatment of AS.
Methods: Sixty-four male C57BL/6J mice were randomly divided into two groups, 12 in the normal control group and 52 in the model group (MOD). Seven weeks later, two mice in each of the above two groups were randomly sacrificed, and the whole aortic tissue of the mice was taken out for hematoxylin-eosin staining.
Objective: To explore the possible mechanism of Tongdu Tiaoshen acupuncture combined with Xiaoxuming decoction (, XXMD) in the treatment of Parkinson's disease (PD).
Methods: C57BL/6 mice were randomly divided into eight groups ( 12), including blank group, model group, medication group, acupuncture group, high-dose XXMD group (XXMD-H), low-dose XXMD group (XXMD-L), acupuncture combined with high-dose XXMD group (A+H), and acupuncture combined with low-dose XXMD group (A+L). After treatment for 6 weeks, dopamine (DA) neurons and the pathological changes of tyrosine hydroxylase (TH) positive cells were observed.
Article Synopsis
- - The study tested the safety and efficacy of EBV-specific CTLs in treating refractory or recurrent angioimmunoblastic T-cell lymphoma (AITL) in nine patients, all at advanced stages (III and IV) with previous chemotherapy treatments.
- - Out of the patients treated, 66.7% showed some response to the therapy, with a 55.6% objective remission rate; notable outcomes included complete remission in two patients with disease progression.
- - Despite some side effects like fever and rash, no severe complications occurred; however, the study indicated a 3-year overall survival rate of 44.4% and a provisional progression-free survival of 33.3%.
[Effect of cystatin from on DSS - induced ulcerative colitis in mice].
Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi
May 2018
Objective: To investigate the effect of cysteine protease inhibitor derived from (SjCystatin) on dextran sodium sulfate (DSS)-induced acute ulcerative colitis in mice.
Methods: Eighteen C57BL/6 mice were randomly divided into three groups: a control group treated with PBS (Group A), a DSS-induced-colitis group treated with PBS (Group B), and a DSS-induced-colitis group treated with SjCystatin (Group C). Colitis was induced in mice by giving 3% DSS orally for 7 days.