Publications by authors named "L I Heller"
Improve Mental Health (Improve-MH) in refugee families using a culturally adapted, general practitioner-delivered psychotherapeutic intervention combined with Triple P Online parenting programme: study protocol of a multicentre randomised controlled trial.
BMJ Open
September 2024
Article Synopsis
- Germany and the EU have seen over 1.6 million refugees since 2014, with many facing challenges like discrimination, poor living conditions, and mental health issues, especially among parents.
- The study aims to improve mental health in refugee parents through a randomized controlled trial involving 188 participants, providing a 10-week intervention focused on parenting skills and mental health support, compared to standard treatment.
- The research is ethically approved and will assess outcomes at multiple stages, running from February 2019 to July 2025, to evaluate both parental and child mental health improvements.
Objectives: Early Childhood Caries is a global health problem. The Bright Smiles Bright Futures (BSBF) program seeks to equip educators, children, and parents with skills and knowledge about oral health promotion habits early in life. The aim of this study was to examine parental perceptions of the BSBF program and identify key facilitators and barriers for its implementation.
View Article and Find Full Text PDFIL-12 and PD-1 peptide combination gene therapy for the treatment of melanoma.
Mol Ther Nucleic Acids
September 2024
Interleukin-12 (IL-12) gene electrotransfer (GET) delivery is highly effective in inducing long-term, complete regression in mouse and human melanoma and other solid tumors. Therapeutic efficacy is enhanced by immune checkpoint inhibitors, and the combination of IL-12 plasmid GET (pIL-12 GET) and anti-programmed cell death protein 1 (PD-1) monoclonal antibodies has reached clinical trials. In this study, we designed peptides and plasmids encoding the mouse homologs of the pembrolizumab and nivolumab programmed cell death 1 ligand 1 (PD-L1) binding regions.
View Article and Find Full Text PDFTick fever agents in Holstein calves grazing in a tropical region: predisposing factors, impact on milk production, productivity, and role of Rhipicephalus microplus in epidemiology.
Vet Parasitol
October 2024
Article Synopsis
- The study assessed the effects of the tick Rhipicephalus microplus on Holstein calves' health and productivity on a tropical dairy farm, focusing on factors impacting tick fever (TF) outbreaks.
- It involved tracking rectal temperatures and blood sampling of calves to diagnose TF agents like Anaplasma marginale and Babesia species, leading to specific treatment protocols.
- Results indicated that factors like colostrum quality, embryo transfer status, and weaning weight affected the recurrence of TF, with each recurrence reducing first lactation milk production by over 200 liters.
Background: Tissues, such as skeletal muscle, have been targeted for the delivery of plasmid DNA (pDNA) encoding vaccines and therapeutics. The application of electric pulses (electroporation or electrotransfer) increases cell membrane permeability to enhance plasmid delivery and expression. However, the molecular effects of DNA electrotransfer on the muscle tissue are poorly characterized.
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