Publications by authors named "L I Hansson"
Addressing the risks of cyanobacterial blooms and toxin production under ongoing and accelerating eutrophication and climate warming is crucial for both water ecosystem services and human health. Therefore, we here explored the interactive effects of eutrophication and warming on freshwater ecosystems, focusing on Microcystis and its cyanotoxin production. We employed a large-scale mesocosm system simulating future climate warming scenarios in concert with varying degrees of nutrient enrichment.
View Article and Find Full Text PDFBackground: It is thought that patients with inborn errors of immunity (IEI) are more susceptible to severe coronavirus disease 2019 (COVID-19) than the general population, but a quantification of this potential risk is largely missing.
Objective: We assessed the impact of COVID-19 on patients with IEI.
Methods: A nationwide cohort study was performed to estimate the relative risk (RR) for hospitalization, intensive care, and death within 30 days after a positive severe acute respiratory syndrome coronavirus 2 test result in an IEI population (n = 2392) compared to the general population (n = 8,270,705) using data from Swedish national registries.
Article Synopsis
- Immunocompromised patients have shown weak responses to initial SARS-CoV-2 mRNA vaccinations, prompting recommendations for extra booster doses; however, real-world data on these recommendations is limited.
- A two-year follow-up of the COVAXID clinical trial involved 364 participants, focusing on their immune responses and the effects of their vaccination schedule and underlying health conditions.
- The study found that while some patients who initially had poor responses improved after additional doses, their immune response remained affected by their immunosuppressive status, emphasizing the need for ongoing vaccination efforts in these populations.
Article Synopsis
- Azithromycin is the main antibiotic used to treat Mycoplasma genitalium (MG), but resistance due to mutations is becoming a concern, particularly in the 23S rRNA gene.
- A study evaluated the Panther Fusion analyzer for detecting macrolide resistance mutations (MRM) and wild type (WT) MG in clinical samples, finding a 91% agreement with an established PCR method.
- The Panther Fusion detected MRM in 20% and WT in 62% of samples, showing potential for easier testing but slightly lower effectiveness for macrolide susceptibility testing, suggesting the need for additional testing methods when results are unclear.
Background: Data on the outcomes of COVID-19 in people living with HIV (PLHIV), specifically in relation to vaccination status, are lacking during the Omicron era.
Methods: This nationwide registry-based study included all resident in Sweden ≥18 years with a positive SARS-CoV-2 PCR test during January 2021-February 2023. We estimated adjusted odds ratios (adjOR) for COVID-19 hospitalisation and severe COVID-19 (ICU admission and 90-day mortality), categorised by SARS-CoV-2 vaccination status (0-1, 2, and ≥3 doses), and HIV-status.