Diagonal earlobe crease: a coronary risk factor, a genetic marker of coronary heart disease, or a mere wrinkle. Ancient Greco-Roman evidence.

In a new study on the relationship between the diagonal earlobe crease (DELC), first described by Frank in 1973, and the presence of chronic ischemic heart disease, four main hypotheses are presented. Hypothesis 1: DELC is a coronary risk factor or a marker of coronary risk factor. Hypothesis 2: DELC is a genetic marker of atherosclerotic coronary disease.