A brief literature review and own clinical experience in prophylaxis of oral mucositis in children using low level laser therapy.

Objective: The article describes the experience of clinical application of low level laser therapy in pediatric oncology for the prevention and treatment of chemotherapy complications such as oral mucositis.

Background: For this purpose, for the first time in the world non-invasive laser blood illumination is used on the sinocarotid zone (on the projection of the common carotid artery symmetrically) and popliteal fossa in order to stimulate the phagocytic activity of leukocytes.

Methods: 25 children with different oncological diseases were given non-invasive laser blood illumination treatment (904 nm, pulse mode, 100 ns, 50-150 Hz, 5-7 W, 4 cm, 1-2 minutes daily per each procedure) 1-3 days before the beginning of chemotherapy.

[Low-intensity laser therapy in pediatric oncology].

Application of low-intensity laser radiotherapy (LILR) allowed to cut down time needed for management of radiation injury and chemotherapy complications in pediatric patients 1.5-2-fold. It was shown that exposure to LIILR caused mononuclear (MN) levels of donors' blood to rise which in turn led to release, in higher concentrations, of IL-1 and FNO cytokins, major factors of immune response development.

[Low-intensity lasers in pediatric oncology].

The paper outlines the outcomes of treatment for complications associated with chemo- and radiation therapy in children with malignant neoplasms by using low-intensity laser radiation. The use of this therapy may reduce the duration of treatment of these complications by 1.5-2 times.