Effects of colchicine adjuvant therapy on disease control, serum NALP3, sICAM-1, MMP-9 and MMP-13 in patients with coronary heart disease and acute gout attack.

Background: To investigate the impact of colchicine adjuvant therapy on disease control and serum levels of nucleotide-binding oligomerization domain-like receptor (NALP) 3, soluble intercellular adhesion molecule (sICAM)-1, matrix metalloproteinase (MMP)-9, and MMP13 in patients with coronary heart disease (CHD) complicated by acute gout attacks.

Methods: Ninety-two patients with CHD and acute gout attacks admitted to our hospital from October 2021 to January 2023 were randomly divided into an observation group and a control group, with 46 patients in each group. The control group received conventional treatment, while the observation group received colchicine adjuvant therapy on top of the control group's treatment for 7 days.

Atractylenolide I ameliorates post-infectious irritable bowel syndrome by inhibiting the polymerase I and transcript release factor and c-Jun N-terminal kinase/inducible nitric oxide synthase pathway.

Objective: To explore the therapeutic effect and target of atractylenolide I (AT-I) on post-infectious irritable bowel syndrome (PI-IBS) rats.

Methods: Therefore, the preliminarily mechanism of AT-I in anti-PI-IBS were first predicted by network pharmacology and molecular docking, then the possible signaling pathways were systematically analyzed. Finally, the potential therapeutic targets and possible signaling pathways of AT-I on PI-IBS in Sprague-Dawley (SD) rat model were verified by experiments.

An updated systematic review, meta-analysis and trial sequential analysis of the efficacy and safety of en bloc transurethral resection vs. conventional transurethral resection for non-muscle-invasive bladder tumor.

Objective: En bloc transurethral resection of bladder tumor (ERBT) for non-muscular invasive bladder tumor (NMIBC) has been used in clinical practice, but its efficacy and safety have not been conclusional. We aimed to evaluate the efficacy and safety of ERBT and conventional transurethral resection of bladder tumor (cTURBT) for NMIBC.

Methods: Randomized controlled trials (RCTs) comparing ERBT and cTURBT in the treatment of NMIBC were searched in Pubmed, Embase, Clinicaltrials.

Global CO uptake by cement materials accounts 1930-2023.

The majority of the carbon footprint of the cement industry originates from the decomposition of alkaline carbonates during clinker production. Recent studies have demonstrated that calcium oxides and other alkaline oxides in cement materials can sequester CO through the carbonation process and partially offset the carbon emissions generated during cement production. This study employs a comprehensive analytical model to estimate the CO uptake via hydrated cement carbonation, including concrete, mortar, construction waste, and cement kiln dust (CKD), covering major cement production and consumption regions worldwide from 1930 to 2023.

The long-term impact of debt relief for indigent defendants in a misdemeanor court.

US courts regularly assess fines, fees, and costs against criminal defendants. Court-related debt can cause continuing court involvement and incarceration, not because of new crimes, but because of unpaid financial obligations. We conducted an experiment with 606 people found guilty of misdemeanors in Oklahoma County, Oklahoma.