Mechanics of the Microtubule Seam Interface Probed by Molecular Simulations and in Vitro Severing Experiments.

Microtubules (MTs) are structural components essential for cell morphology and organization. It has recently been shown that defects in the filament's lattice structure can be healed to create stronger filaments in a local area and ultimately cause global changes in MT organization and cell mobility. The ability to break, causing a defect, and heal appears to be a physiologically relevant and important feature of the MT structure.

Katanin catalyzes microtubule depolymerization independently of tubulin C-terminal tails.

Microtubule network remodeling is an essential process for cell development, maintenance, cell division, and motility. Microtubule-severing enzymes are key players in the remodeling of the microtubule network; however, there are still open questions about their fundamental biochemical and biophysical mechanisms. Here, we explored the ability of the microtubule-severing enzyme katanin to depolymerize stabilized microtubules.

[The influence of liposuction on the blood leptin level].

The level of serum leptin was studied in 20 patients before and after liposuction carried out for excessive subcutaneous fatty tissue. The dynamics of indices depending on the volume of the ablated fatty tissue was analyzed. It was found that in most patients the level of blood serum leptin correlated with the body mass and fatty tissue index.

[Various aspects of organization of microsurgical autologous transplantation of composite skin flaps].

An experience with 137 microsurgical transplantations enabled the authors to consider questions of rational organization of these complex, and severe operations. Different variants of work of the second team of surgeons are analyzed aimed at shortening the duration of the operation and getting less load by its participants.