Sporadic deficient mismatch repair in colorectal cancer increases the risk for non-colorectal malignancy: A European multicenter cohort study.

Background And Objectives: Disparities between tumors arising via different sporadic carcinogenetic pathways have not been studied systematically. This retrospective multicenter cohort study evaluated the differences in the risk for non-colorectal malignancy between sporadic colorectal cancer (CRC) patients from different DNA mismatch repair status.

Methods: A retrospective European multicenter cohort study including in total of 1706 CRC patients treated between 1996 and 2019 in three different countries.

Colon cancer patients with mismatch repair deficiency are more likely to present as acute surgical cases.

Background: The effect of the genetic imprint on the emergency presentation of colon cancer remains unclear. The disparity between tumours evolving along different carcinogenetic pathways has not been studied systematically. This retrospective multicenter cohort study evaluates the association between mismatch repair status and the risk for acute surgery of colon cancer.

[Enzalutamide and Abiraterone in the Treatment of Metastatic Castration-resistant Prostate Cancer after Chemotherapy].

Aim: Enzalutamide and abiraterone represent new therapeutical options in the treatment of metastatic castration-resistant prostate cancer (mCRPC). The aim of the presented study was retrospective analysis of clinical experience and efficacy of enzalutamide or abiraterone in the postchemo indication in patients with mCRPC.

Patients And Methods: A total of 32 mCRPC patients were evaluated.

Distribution of the platinum group elements in peat deposit near a historic lead and silver mining district.

Concentrations of platinum group elements (PGE) and Ag were studied in a minerotrophic peat deposit near a historic Pb-Ag mining district (Príbram, Czech Republic). The PGE determinations were performed by quadrupole ICP-MS after NiS fire assay procedure. In the individual peat layers (dated by measurement of (210)Pb activity) the PGE concentrations were low and ranged from 0.