Publications by authors named "L I Banla"
Unlabelled: Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation in off-target sites of toxicity. As proof-of-principle, we tested whether this strategy of " dionuclide nduced rug ngagement for elease" ( ) could locally deliver combined radiation and chemotherapy to maximize tumor cytotoxicity while minimizing exposure to activated chemotherapy in off-target sites.
View Article and Find Full Text PDFThe R's of Radiation Therapy: Do We Need More or Do We Move On?
Int J Radiat Oncol Biol Phys
July 2024
Article Synopsis
- The study focuses on improving cancer treatment by combining X-ray radiation therapy (XRT) with a new type of nanoparticle that releases drugs specifically in tumor tissues when activated by radiation, aiming to enhance treatment efficacy while reducing side effects.
- The proposed method uses scintillating nanoparticles to create localized "drug depots" in tumors, allowing for the targeted release of a cancer-killing drug called MMAE upon exposure to XRT.
- Testing in mouse models showed that this approach not only effectively released the drug but also outperformed XRT alone in killing tumor cells, suggesting a promising strategy for more effective cancer treatments.
Introduction: Thoracic radiotherapy (TRT) is increasingly used in patients receiving osimertinib for advanced NSCLC, and the risk of pneumonitis is not established. We investigated the risk of pneumonitis and potential risk factors in this population.
Methods: We performed a multi-institutional retrospective analysis of patients under active treatment with osimertinib who received TRT between April 2016 and July 2022 at two institutions.
The human gastrointestinal tract (GIT) is inhabited by a dense microbial community of symbionts. Enterococci are among the earliest members of this community and remain core members of the GIT microbiota throughout life. Enterococci have also recently emerged as opportunistic pathogens and major causes of nosocomial infections.
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