Publications by authors named "L Hviid"
Background: Acquired immunity to Plasmodium falciparum malaria is mainly mediated by immunoglobulin G (IgG) targeting erythrocyte membrane protein 1 (PfEMP1). These adhesins mediate infected erythrocyte (IE) sequestration, protecting IEs from splenic destruction. PfEMP1-specific IgG is therefore thought to protect mainly by inhibiting IE sequestration.
View Article and Find Full Text PDFCircumsporozoite protein-specific active and passive immunization can protect significantly against Plasmodium falciparum malaria and are being considered as tools to prevent placental malaria. Despite recent encouraging findings, a closer view of the underlying biology indicates significant challenges to preventing placental malaria.
View Article and Find Full Text PDFHeterozygous carriers of haemoglobin S and C (HbAS and HbAC) have a reduced risk of severe malaria but are not protected from Plasmodium falciparum infection, suggesting that the protection involves acquired immunity. During a blood meal, female Anopheles mosquitoes inject saliva that can elicit a host antibody response, which can serve as a proxy for exposure to Plasmodium infection. Previous studies have shown that the peptide gSG6-P1 of An.
View Article and Find Full Text PDFArticle Synopsis
- The most severe form of malaria, caused by Plasmodium falciparum, remains a major issue, contributing significantly to human suffering and poverty.
- PfEMP1 is a crucial antigen that allows infected red blood cells to adhere to blood vessel linings, playing a key role in the disease's development and the body's immune response.
- The chapter reviews advancements in understanding PfEMP1's structure, function, and immune interactions since 2015, highlighting research on vaccines and future directions in malaria treatment.