Publications by authors named "L Huser"
Article Synopsis
- Advancing age makes it harder for people to fight skin melanoma, a type of skin cancer.
- Scientists found that tiny particles called extracellular vesicles (EVs) from older cells change in content, even though they look the same as those from younger cells.
- A special protein called CD9 decreases as we age, which affects how these EVs can help tumors grow, making older cells better at supporting cancer.
Article Synopsis
- Cutaneous melanoma shows a notable sex disparity in how often it occurs and affects different genders, particularly worsening with age, but the reasons behind this are not fully understood.* -
- The study reveals that skin fibroblasts from older males experience changes that lead to increased melanoma cell invasiveness and resistance to treatment, impacting the behavior of tumors in older male mice.* -
- A specific protein, BMP2, is linked to the more aggressive characteristics of melanoma cells in aged males, and blocking its action can make these cancer cells more responsive to certain treatments.*
Melanoma, the most lethal form of skin cancer, often has worse outcomes in older patients. We previously demonstrated that an age-related decrease in the secreted extracellular matrix (ECM) protein HAPLN1 has a role in slowing melanoma progression. Here we show that HAPLN1 in the dermal ECM is sufficient to maintain the integrity of melanoma-associated blood vessels, as indicated by increased collagen and VE-cadherin expression.
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- Pancreatic cancer is more common in older people and tends to have a worse prognosis for them due to various factors in the tumor microenvironment.
- Research focused on how aged pancreatic fibroblasts, which influence cancer progression, secrete more growth/differentiation factor 15 (GDF-15) compared to younger fibroblasts.
- GDF-15 promotes tumor growth by activating the AKT signaling pathway, indicating that age-related changes in the pancreatic microenvironment contribute to cancer progression and could lead to new treatment strategies.
In the vertebrate retina, several dozens of parallel channels relay information about the visual world to the brain. These channels are represented by the different types of retinal ganglion cells (RGCs), whose responses are rendered selective for distinct sets of visual features by various mechanisms. These mechanisms can be roughly grouped into synaptic interactions and cell-intrinsic mechanisms, with the latter including dendritic morphology as well as ion channel complement and distribution.
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