Publications by authors named "L Hummer"
FLT3 mutations occur in approximately 25% of all acute myeloid leukemia (AML) patients. While several FLT3 inhibitors have received FDA approval, their use is currently limited to combination therapies with chemotherapy, as resistance occurs, and efficacy decreases when the inhibitors are used alone. Given the highly heterogeneous nature of AML, there is an urgent need for novel targeted therapies that address the disease from multiple angles.
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- Acute myeloid leukemia (AML) is a serious blood cancer that is hard to treat, and scientists are studying a part of the immune system called the NLRP3 inflammasome to understand its role in AML.
- Researchers looked at gene expressions in AML patients and created special cells to study how NLRP3 affects AML cell survival.
- They found that higher levels of NLRP3 are linked to worse outcomes for patients, and blocking NLRP3 helps make AML cells die, which could lead to new treatments for the disease.
Article Synopsis
- - Replicated 21 experimental studies from reputable journals (Nature and Science, 2010-2015) using rigorous methods, including pre-registered analysis plans and larger sample sizes, averaging five times bigger than the originals.
- - Out of the replications, 62% showed effects consistent with the original studies, but the average effect size was about 50% of what was originally reported.
- - The study found that researchers’ beliefs about replicability were linked to actual outcomes, indicating that the scientific community can often predict which results are likely to replicate, suggesting that failures are not purely due to random chance.
An instrument to measure total integrated scattering (TIS) in space was built as part of the Optical Properties Monitor instrument package and flown on the Russian Mir Space Station in a low Earth orbit. TIS at two wavelengths was measured in space at approximately weekly intervals from 29 April to 26 December 1997 and telemetered to Earth during the mission. Of the 20 TIS samples, 13 are described here to illustrate the performance of the TIS instrument.
View Article and Find Full Text PDFWith a radioimmunoassay using hPTH 1-34 for antibody production, for radioiodination and as a standard, hPTH 1-34 was detectable (detection limit 40 pg/ml) preoperatively in peripheral blood in 14 of 29 patients with hyperparathyroidism, but in no controls. In all patients with parathyroid adenoma and detectable hPTH 1-34 preoperatively, the values fell after parathyroid surgery. Contrastingly, three of four patients with diffuse parathyroid hyperplasia and two of three with normal parathyroid glands showed a rise in hPTH 1-34 postoperatively, which was concomitant with very low serum calcium levels.
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