Publications by authors named "L Hooghe"

Support for Ukraine against Russian aggression has been strong across Europe, but it is far from uniform. An expert survey of the positions taken by political parties in 29 countries conducted mid-2023 reveals that 97 of 269 parties reject one or more of the following: providing weapons, hosting refugees, supporting Ukraine's path to European Union membership, or accepting higher energy costs. Where the perceived threat from Russia is most severe, we find the greatest levels of support for Ukraine.

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Unlabelled: Why do some international organizations (IO) accrete delegated authority over time while in others delegation is static or declines? We hypothesize that the dynamics of delegation are shaped by an IO's founding contract. IOs rooted in an open-ended contract have the capacity to discover cooperation over time: as new problems arise these IOs can adopt new policies or strengthen collaboration in existing areas. This, in turn, triggers a demand for delegation.

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Article Synopsis
  • Rozanolixizumab (UCB7665) is a monoclonal antibody designed to target and reduce harmful IgG antibodies in autoimmune and alloimmune diseases by inhibiting the neonatal Fc receptor (FcRn).
  • Studies show that this antibody effectively lowers plasma IgG levels in animal models (mice and cynomolgus monkeys) without affecting albumin levels and demonstrates a good safety profile during prolonged administration.
  • Current research includes clinical trials for conditions like immune thrombocytopenia and myasthenia gravis, suggesting rozanolixizumab could be a promising new treatment option for these diseases.
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A major role for FcRn is the salvage of pinocytosed IgG and albumin from a degradative fate in lysosomes. FcRn achieves this by binding IgG in a pH-dependent manner in acidic endosomes and recycling it to the plasma membrane to be released at neutral pH. This is important in maintaining high serum IgG and albumin levels and has the potential to be exploited to modulate the pharmacokinetics of antibody-based therapeutics.

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