Publications by authors named "L Hjelte"
Article Synopsis
- - The study examined the effects of lumacaftor/ivacaftor on lung function and microbial presence in cystic fibrosis (CF) patients homozygous for F508del over one year.
- - Results showed significant improvements in lung function (ppFEV1) and body mass index (BMI) among both adults and children and a reduction in the prevalence of certain CF-related respiratory microorganisms.
- - However, key pathogens did not show significant changes, indicating that while some improvements were seen, the overall microbiological burden may not have diminished as expected.
Viral respiratory tract infections exacerbate airway disease and facilitate life-threatening bacterial colonization in cystic fibrosis (CF). Annual influenza vaccination is recommended and vaccines against other common respiratory viruses may further reduce pulmonary morbidity risk. Enteroviruses have been found in nasopharyngeal samples from CF patients experiencing pulmonary exacerbations.
View Article and Find Full Text PDFBackground: Chronic obstructive pulmonary disease (COPD) is characterized by persistent airflow limitation associated with chronic inflammation in the airways. Mucosal-associated invariant T (MAIT) cells are unconventional, innate-like T cells highly abundant in mucosal tissues including the lung. We hypothesized that the characteristics of MAIT cells in circulation may be prospectively associated with COPD morbidity.
View Article and Find Full Text PDFis commonly isolated from CF airways. However, the impact on CF lung progression is not completely understood. In this study, using a 16-year retrospective observational cohort study (2000-2015) that included 132 patients, we determined the annual lung function, measured as percent predicted forced expiratory volume in the first second (ppFEV1), decline before and after the first colonization with .
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